Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7

Spinocerebellar ataxia type 7 (SCA7) is a dominantly inherited neurodegenerative disorder caused by a CAG – polyglutamine (polyQ) repeat expansion in the ataxin-7 gene. In polyQ disorders, synaptic dysfunction and neurodegeneration may develop prior to symptom onset. However, conditional expression...

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Main Authors: Furrer, Stephanie A., Waldherr, Sarah M., Mohanachandran, Mathini S., Baughn, Travis D., Nguyen, Kien-Thiet, Sopher, Bryce L., Damian, Vincent A., Garden, Gwenn A., La Spada, Albert R.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561911/
https://ncbi.nlm.nih.gov/pubmed/23197655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds495
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