A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

We describe a protocol for the rapid and sensitive quantification of disease severity in mouse models of cerebella ataxia. It is derived from previously published phenotype assessments in several disease models, including spinocerebellar ataxias, Huntington s disease and spinobulbar muscular atrophy...

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Detalhes bibliográficos
Main Authors: Guyenet, Stephan J., Furrer, Stephanie A., Damian, Vincent M., Baughan, Travis D., La Spada, Albert R., Garden, Gwenn A.
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2010
Assuntos:
JoVE Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121238/
https://ncbi.nlm.nih.gov/pubmed/20495529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/1787
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