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Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3
Protein cleavage is a common feature in human neurodegenerative disease. Ataxin-3 protein with an expanded polyglutamine (polyQ) repeat causes spinocerebellar ataxia type-3 (SCA3), also called Machado–Joseph disease, and is cleaved in mammalian cells, transgenic mice and SCA3 patient brain tissue. H...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2778376/ https://ncbi.nlm.nih.gov/pubmed/19783548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp456 |
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