Posttranslational Modification of Ataxin-7 at Lysine 257 Prevents Autophagy-Mediated Turnover of an N-Terminal Caspase-7 Cleavage Fragment

Polyglutamine (polyQ) expansion within the ataxin-7 protein, a member of the STAGA [SPT3-TAF(II)31-GCN5L acetylase] and TFTC (GCN5 and TRRAP) chromatin remodeling complexes, causes the neurodegenerative disease spinocerebellar ataxia type 7 (SCA7). Proteolytic processing of ataxin-7 by caspase-7 gen...

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Detalhes bibliográficos
Main Authors: Mookerjee, Shona, Papanikolaou, Theodora, Guyenet, Stephan J., Sampath, Vanitha, Lin, Amy, Vitelli, Cathy, DeGiacomo, Francesco, Sopher, Bryce L., Chen, Sylvia F., La Spada, Albert R., Ellerby, Lisa M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907146/
https://ncbi.nlm.nih.gov/pubmed/19955365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4720-09.2009
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