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Quantitative Description of a Protein Fitness Landscape Based on Molecular Features
Understanding the driving forces behind protein evolution requires the ability to correlate the molecular impact of mutations with organismal fitness. To address this issue, we employ here metallo-β-lactamases as a model system, which are Zn(II) dependent enzymes that mediate antibiotic resistance....
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| Publicado no: | Mol Biol Evol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476158/ https://ncbi.nlm.nih.gov/pubmed/25767204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msv059 |
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