Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

Childhood acute lymphoblastic leukemia can often be retraced to a pre-leukemic clone carrying a prenatal genetic lesion. Postnatally acquired mutations then drive clonal evolution towards overt leukemia. RAG1-RAG2 and AID enzymes, the diversifiers of immunoglobulin genes, are strictly segregated to...

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Pubblicato in:Nat Immunol
Autori principali: Swaminathan, Srividya, Klemm, Lars, Park, Eugene, Papaemmanuil, Elli, Ford, Anthony, Kweon, Soo-Mi, Trageser, Daniel, Hasselfeld, Brian, Henke, Nadine, Mooster, Jana, Geng, Huimin, Schwarz, Klaus, Kogan, Scott C., Casellas, Rafael, Schatz, David G., Lieber, Michael R, Greaves, Mel F., Müschen, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475638/
https://ncbi.nlm.nih.gov/pubmed/25985233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3160
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