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Poly-microbial sepsis increases susceptibility to chronic viral infection and exacerbates CD8(+) T cell exhaustion

Patients who survive sepsis display suppressed immune functions, often manifested as an increased susceptibility to secondary infections. Recently, using a cecal-ligation and puncture (CLP) model of sepsis we showed that sepsis induces substantial and long-lasting changes in the available naive CD8(...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Condotta, Stephanie A., Khan, Shaniya H., Rai, Deepa, Griffith, Thomas S., Badovinac, Vladimir P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475506/
https://ncbi.nlm.nih.gov/pubmed/25980007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402473
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