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Polymicrobial sepsis alters Ag-dependent and -independent memory CD8 T cell functions

Mortality from sepsis frequently results from secondary infections, and the extent to which sepsis affects pathogen-specific memory CD8 T cell responses remains unknown. Using the cecal-ligation and puncture (CLP) model of polymicrobial sepsis, we observed rapid apoptosis of pre-existing memory CD8...

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Main Authors: Duong, Sean, Condotta, Stephanie A., Rai, Deepa, Martin, Matthew D., Griffith, Thomas S., Badovinac, Vladimir P.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001259/
https://ncbi.nlm.nih.gov/pubmed/24646738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303460
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