Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation

The synthesis of Type I collagen, the main component of the bone matrix, precedes the expression of Runx2, the earliest determinant of osteoblast differentiation. We hypothesized that the osteoblast's energetic needs might explain this apparent paradox. We show here that glucose, the main nutri...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell
Prif Awduron: Wei, Jianwen, Shimazu, Junko, Makinistoglu, Munevver P., Maurizi, Antonio, Kajimura, Daisuke, Zong, Haihong, Takarada, Takeshi, lezaki, Takashi, Pessin, Jeffrey E., Hinoi, Eiichi, Karsenty, Gerard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475280/
https://ncbi.nlm.nih.gov/pubmed/26091038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.05.029
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