Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation

The synthesis of Type I collagen, the main component of the bone matrix, precedes the expression of Runx2, the earliest determinant of osteoblast differentiation. We hypothesized that the osteoblast's energetic needs might explain this apparent paradox. We show here that glucose, the main nutri...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Wei, Jianwen, Shimazu, Junko, Makinistoglu, Munevver P., Maurizi, Antonio, Kajimura, Daisuke, Zong, Haihong, Takarada, Takeshi, lezaki, Takashi, Pessin, Jeffrey E., Hinoi, Eiichi, Karsenty, Gerard
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475280/
https://ncbi.nlm.nih.gov/pubmed/26091038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.05.029
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