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Regulation of DNA methylation dictates Cd4 gene expression during development of helper and cytotoxic T cell lineages

During development, progenitor cells with binary potential give rise to daughter cells that have distinct functions. Heritable epigenetic mechanisms then lock in gene expression programs that define lineage identity. Cd4 regulation in helper and cytotoxic T cells exemplifies this process, with enhan...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Immunol
Hauptverfasser: Sellars, MacLean, Huh, Jun R., Day, Kenneth, Issuree, Priya D., Galan, Carolina, Gobeil, Stephane, Absher, Devin, Green, Michael R., Littman, Dan R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474743/
https://ncbi.nlm.nih.gov/pubmed/26030024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3198
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