Treg-Resistant Cytotoxic CD4(+) T Cells Dictate T Helper Cells in Their Vicinity: TH17 Skewing and Modulation of Proliferation

Cytotoxic CD4(+) T cells (CD4 CTL) are terminally differentiated T helper cells that contribute to autoimmune diseases, such as multiple sclerosis. We developed a novel triple co-culture transwell assay to study mutual interactions between CD4 CTL, conventional TH cells, and regulatory T cells (Treg...

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Опубликовано в: :Int J Mol Sci
Главные авторы: Hoeks, Cindy, Vanheusden, Marjan, Peeters, Liesbet M., Stinissen, Piet, Broux, Bieke, Hellings, Niels
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8198086/
https://ncbi.nlm.nih.gov/pubmed/34073458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115660
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