Regulation of DNA methylation dictates Cd4 gene expression during development of helper and cytotoxic T cell lineages

During development, progenitor cells with binary potential give rise to daughter cells that have distinct functions. Heritable epigenetic mechanisms then lock in gene expression programs that define lineage identity. Cd4 regulation in helper and cytotoxic T cells exemplifies this process, with enhan...

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Pubblicato in:Nat Immunol
Autori principali: Sellars, MacLean, Huh, Jun R., Day, Kenneth, Issuree, Priya D., Galan, Carolina, Gobeil, Stephane, Absher, Devin, Green, Michael R., Littman, Dan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474743/
https://ncbi.nlm.nih.gov/pubmed/26030024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3198
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