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Intermolecular carbene S–H insertion catalysed by engineered myoglobin-based catalysts

The first example of a biocatalytic strategy for the synthesis of thioethers via an intermolecular carbene S–H insertion reaction is reported. Engineered variants of sperm whale myoglobin were found to efficiently catalyze this C–S bond forming transformation across a diverse set of aryl and alkyl m...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Tyagi, Vikas, Bonn, Rachel B., Fasan, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474517/
https://ncbi.nlm.nih.gov/pubmed/26101581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00080g
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