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Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
Toll-like receptor (TLR) agonists activate both the innate and the adaptive immune systems. These TLR agonists have been exploited as potent vaccine adjuvants and antitumor agents. We describe the identification and characterization of a small molecule, N-methyl-4-nitro-2-(4-(4-(trifluoromethyl)phen...
Sparad:
| I publikationen: | Sci Adv |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Association for the Advancement of Science
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4474499/ https://ncbi.nlm.nih.gov/pubmed/26101787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1400139 |
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