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Discovery of small molecule inhibitors of the TLR1-TLR2 complex
The protein complex of toll-like receptor 1 and 2 (TLR1/2) is an important regulator of innate immunity, and therefore provides an attractive target for the treatment of various immune disordres. Here we report a novel compound (CU-CPT22) that can compete with the synthetic triacylated lipoprotein (...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510333/ https://ncbi.nlm.nih.gov/pubmed/22969053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201204910 |
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