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Small Molecule Fluoride Toxicity Agonists

Fluoride is a ubiquitous anion that inhibits a wide variety of metabolic processes. Here we report the identification of a series of compounds that enhance fluoride toxicity in Escherichia coli and Streptococcus mutans. These molecules were isolated by using a high-throughput screen (HTS) for compou...

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Publicat a:Chem Biol
Autors principals: Nelson1, James W., Plummer, Mark S., Blount, Kenneth F., Ames, Tyler D., Breaker, Ronald R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617673/
https://ncbi.nlm.nih.gov/pubmed/25910244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.03.016
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