Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production

Degradation of elastin leads to the production of elastin-derived peptides (EDP), which exhibit several biological effects, such as cell proliferation or protease secretion. Binding of EDP on the elastin receptor complex (ERC) triggers lactosylceramide (LacCer) production and ERK1/2 activation follo...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Scandolera, Amandine, Rabenoelina, Fanja, Chaintreuil, Carine, Rusciani, Anthony, Maurice, Pascal, Blaise, Sébastien, Romier-Crouzet, Béatrice, El Btaouri, Hassan, Martiny, Laurent, Debelle, Laurent, Duca, Laurent
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473072/
https://ncbi.nlm.nih.gov/pubmed/26086247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129994
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