Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production

Degradation of elastin leads to the production of elastin-derived peptides (EDP), which exhibit several biological effects, such as cell proliferation or protease secretion. Binding of EDP on the elastin receptor complex (ERC) triggers lactosylceramide (LacCer) production and ERK1/2 activation follo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Scandolera, Amandine, Rabenoelina, Fanja, Chaintreuil, Carine, Rusciani, Anthony, Maurice, Pascal, Blaise, Sébastien, Romier-Crouzet, Béatrice, El Btaouri, Hassan, Martiny, Laurent, Debelle, Laurent, Duca, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473072/
https://ncbi.nlm.nih.gov/pubmed/26086247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129994
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