Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9

The genomic DNAs of tailed bacteriophages are commonly modified by the attachment of chemical groups. Some forms of DNA modification are known to protect phage DNA from cleavage by restriction enzymes, but others are of unknown function. Recently, the CRISPR-Cas nuclease complexes were shown to medi...

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Bibliographic Details
Published in:mBio
Main Authors: Bryson, Alexandra L., Hwang, Young, Sherrill-Mix, Scott, Wu, Gary D., Lewis, James D., Black, Lindsay, Clark, Tyson A., Bushman, Frederic D.
Format: Artigo
Language:Inglês
Published: American Society of Microbiology 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471564/
https://ncbi.nlm.nih.gov/pubmed/26081634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00648-15
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