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Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1)

Extracellular nucleotides acting through P2 receptors facilitate natriuresis. To define how purinergic mechanisms are involved in sodium homeostasis, we used transgenic (TG) mice that globally overexpress human CD39 (hCD39, NTPDase1), an ectonucleotidase that hydrolyzes extracellular ATP/ADP to AMP,...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Renal Physiol
Main Authors: Zhang, Yue, Robson, Simon C., Morris, Kaiya L., Heiney, Kristina M., Dwyer, Karen M., Kishore, Bellamkonda K., Ecelbarger, Carolyn M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469885/
https://ncbi.nlm.nih.gov/pubmed/25877509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00125.2014
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