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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Background: The number of Mendelian randomization analyses including large numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome-wide association studies, and the desire to obtain more precise estimates of causal effects. However, some genetic variants may not...

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Podrobná bibliografie
Vydáno v:Int J Epidemiol
Hlavní autoři: Bowden, Jack, Davey Smith, George, Burgess, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469799/
https://ncbi.nlm.nih.gov/pubmed/26050253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyv080
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