Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the [Formula: see text] statistic

Background: MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect from multiple individual variants, which is robust to invalid instruments. It can be used to test for directional pleiotropy and prov...

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Bibliografske podrobnosti
izdano v:Int J Epidemiol
Main Authors: Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Davey Smith, George, Sheehan, Nuala A, Thompson, John R
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Mendelian Randomisation and Instrumental Variable Analysis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446088/
https://ncbi.nlm.nih.gov/pubmed/27616674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyw220
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