A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization

Mendelian randomization (MR) uses genetic data to probe questions of causality in epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent years, it has become commonplace to attempt MR analyses by synthesising summary data estimates of genetic association gleaned...

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Bibliografiske detaljer
Udgivet i:Stat Med
Main Authors: Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Davey Smith, George, Sheehan, Nuala, Thompson, John
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434863/
https://ncbi.nlm.nih.gov/pubmed/28114746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7221
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