A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization

Mendelian randomization (MR) uses genetic data to probe questions of causality in epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent years, it has become commonplace to attempt MR analyses by synthesising summary data estimates of genetic association gleaned...

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Detalhes bibliográficos
Publicado no:Stat Med
Main Authors: Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Davey Smith, George, Sheehan, Nuala, Thompson, John
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434863/
https://ncbi.nlm.nih.gov/pubmed/28114746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7221
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