Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

BACKGROUND: Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR usi...

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Bibliografske podrobnosti
izdano v:Int J Epidemiol
Main Authors: Hartwig, Fernando Pires, Davey Smith, George, Bowden, Jack
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Methods
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837715/
https://ncbi.nlm.nih.gov/pubmed/29040600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyx102
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