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Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization—A Job for the Humble Heterogeneity Statistic?

Mendelian randomization (MR) is gaining in recognition and popularity as a method for strengthening causal inference in epidemiology by utilizing genetic variants as instrumental variables. Concurrently with the explosion in empirical MR studies, there has been the steady production of new approache...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Epidemiol
Hauptverfasser: Bowden, Jack, Hemani, Gibran, Davey Smith, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269239/
https://ncbi.nlm.nih.gov/pubmed/30188969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/aje/kwy185
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