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Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization—A Job for the Humble Heterogeneity Statistic?

Mendelian randomization (MR) is gaining in recognition and popularity as a method for strengthening causal inference in epidemiology by utilizing genetic variants as instrumental variables. Concurrently with the explosion in empirical MR studies, there has been the steady production of new approache...

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Detalhes bibliográficos
Publicado no:Am J Epidemiol
Main Authors: Bowden, Jack, Hemani, Gibran, Davey Smith, George
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269239/
https://ncbi.nlm.nih.gov/pubmed/30188969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/aje/kwy185
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