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An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings

BACKGROUND: Mendelian randomization (MR) is a powerful tool in epidemiology that can be used to estimate the causal effect of an exposure on an outcome in the presence of unobserved confounding, by utilizing genetic variants that are instrumental variables (IVs) for the exposure. This has been exten...

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Détails bibliographiques
Publié dans:Int J Epidemiol
Auteurs principaux: Sanderson, Eleanor, Davey Smith, George, Windmeijer, Frank, Bowden, Jack
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734942/
https://ncbi.nlm.nih.gov/pubmed/30535378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyy262
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