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Detecting and correcting for bias in Mendelian randomization analyses using Gene-by-Environment interactions

BACKGROUND: Mendelian randomization (MR) has developed into an established method for strengthening causal inference and estimating causal effects, largely due to the proliferation of genome-wide association studies. However, genetic instruments remain controversial, as horizontal pleiotropic effect...

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Detalhes bibliográficos
Publicado no:Int J Epidemiol
Main Authors: Spiller, Wes, Slichter, David, Bowden, Jack, Davey Smith, George
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659360/
https://ncbi.nlm.nih.gov/pubmed/30462199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyy204
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