Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma

BACKGROUND: Ipilimumab improves overall survival in a subset of patients with metastatic melanoma. Peripheral blood T cell receptor (TCR) repertoire diversity has been associated with favorable outcomes in patients with cancer, but its relevance as a biomarker for ipilimumab outcomes remains unknown...

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Dades bibliogràfiques
Publicat a:J Immunother Cancer
Autors principals: Postow, Michael A., Manuel, Manuarii, Wong, Phillip, Yuan, Jianda, Dong, Zhiwan, Liu, Cailian, Perez, Solène, Tanneau, Isabelle, Noel, Marlène, Courtier, Anaïs, Pasqual, Nicolas, Wolchok, Jedd D.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469400/
https://ncbi.nlm.nih.gov/pubmed/26085931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-015-0070-4
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