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Immunomodulatory Therapy for Melanoma: Ipilimumab and Beyond

In 2011, the FDA approved the first new therapy for melanoma in over a decade, ipilimumab (Yervoy). Ipilimumab is a novel antibody that blockscytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a regulatory molecule expressed on activated T cells. Blockade of this important immune checkpoint can l...

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Bibliografiske detaljer
Main Authors: Callahan, Margaret K., Postow, Michael A., Wolchok, Jedd D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653249/
https://ncbi.nlm.nih.gov/pubmed/23438382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clindermatol.2012.08.006
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