Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies

[Image: see text] N-[(3-Aminomethyl)benzyl]acetamidine derivatives were synthesized and in vitro evaluated as inhibitors of the inducible isoform of nitric oxide synthase (iNOS). Because of the high potency of action and the excellent selectivity over the endothelial nitric oxide synthase (eNOS), co...

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Publicat a:ACS Med Chem Lett
Autors principals: Maccallini, Cristina, Montagnani, Monica, Paciotti, Roberto, Ammazzalorso, Alessandra, De Filippis, Barbara, Di Matteo, Mauro, Di Silvestre, Sara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Potenza, Maria A., Re, Nazzareno, Pandolfi, Assunta, Amoroso, Rosa
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468396/
https://ncbi.nlm.nih.gov/pubmed/26101565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00149
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