Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies

[Image: see text] N-[(3-Aminomethyl)benzyl]acetamidine derivatives were synthesized and in vitro evaluated as inhibitors of the inducible isoform of nitric oxide synthase (iNOS). Because of the high potency of action and the excellent selectivity over the endothelial nitric oxide synthase (eNOS), co...

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Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Maccallini, Cristina, Montagnani, Monica, Paciotti, Roberto, Ammazzalorso, Alessandra, De Filippis, Barbara, Di Matteo, Mauro, Di Silvestre, Sara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Potenza, Maria A., Re, Nazzareno, Pandolfi, Assunta, Amoroso, Rosa
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468396/
https://ncbi.nlm.nih.gov/pubmed/26101565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00149
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