Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells

Sorafenib, a tyrosine kinase inhibitor, has been demonstrated to exert anti-tumor effects. However, the molecular mechanisms underlying its effects on bladder cancer remain unknown. Here, we evaluated the mechanisms responsible for the sorafenib-induced anti-tumor effects on 5637 and T24 bladder can...

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Detalhes bibliográficos
Publicado no:Oncoscience
Main Authors: Amantini, Consuelo, Morelli, Maria Beatrice, Santoni, Matteo, Soriani, Alessandra, Cardinali, Claudio, Farfariello, Valerio, Eleuteri, Anna Maria, Bonfili, Laura, Mozzicafreddo, Matteo, Nabissi, Massimo, Cascinu, Stefano, Santoni, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468325/
https://ncbi.nlm.nih.gov/pubmed/26097873
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