Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner

Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma. Herein we demonstrated that the TKI axitinib induces DN...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Cardinali, Claudio, Santoni, Matteo, Bernardini, Giovanni, Santoni, Angela, Santoni, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356889/
https://ncbi.nlm.nih.gov/pubmed/27926485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13769
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