Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner

Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma. Herein we demonstrated that the TKI axitinib induces DN...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Cardinali, Claudio, Santoni, Matteo, Bernardini, Giovanni, Santoni, Angela, Santoni, Giorgio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356889/
https://ncbi.nlm.nih.gov/pubmed/27926485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13769
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