Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells

BACKGROUND: Tyrosine kinase inhibitors (TKI) such as sunitinib and pazopanib display their efficacy in a variety of solid tumours. However, their use in therapy is limited by the lack of evidence about the ability to induce cell death in cancer cells. Our aim was to evaluate cytotoxic effects induce...

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Detalhes bibliográficos
Main Authors: Santoni, M, Amantini, C, Morelli, M B, Liberati, S, Farfariello, V, Nabissi, M, Bonfili, L, Eleuteri, A M, Mozzicafreddo, M, Burattini, L, Berardi, R, Cascinu, S, Santoni, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749583/
https://ncbi.nlm.nih.gov/pubmed/23887605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.420
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