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Molecular modeling of the human P2Y(14) receptor: A template for structure-based design of selective agonist ligands

The P2Y(14) receptor (P2Y(14)R) is a G(i) protein-coupled receptor that is activated by uracil nucleotides UDP and UDP-glucose. The P2Y(14)R structure has yet to be solved through X-ray crystallography, but the recent agonist-bound crystal structure of the P2Y(12)R provides a potentially suitable te...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Trujillo, Kevin, Paoletta, Silvia, Kiselev, Evgeny, Jacobson, Kenneth A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468048/
https://ncbi.nlm.nih.gov/pubmed/25868749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.03.042
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