Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays

The proprotein convertase furin is implicated in a variety of pathogenic processes such as bacterial toxin activation, viral propagation, and cancer. Several groups have identified non-peptide compounds with high inhibitory potency against furin in vitro, although their efficacy in various cellbased...

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Bibliographic Details
Published in:Biochem Pharmacol
Main Authors: Ramos-Molina, Bruno, Lick, Adam N., Blanco, Elias H., Posada-Salgado, J. Alejandro, Martinez-Mayorga, Karina, Johnson, Alan T., Jiao, Guan-Sheng, Lindberg, Iris
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468025/
https://ncbi.nlm.nih.gov/pubmed/26003844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.05.008
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