Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine

Furin plays a crucial role in embryogenesis and homeostasis and in diseases such as Alzheimer's disease, cancer, and viral and bacterial infections. Thus, inhibition of furin may provide a feasible and promising approach for therapeutic intervention of furin-mediated disease mechanisms. Here, w...

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Autors principals: Jiao, Guan-Sheng, Cregar, Lynne, Wang, Jinzhi, Millis, Sherri Z., Tang, Cho, O'Malley, Sean, Johnson, Alan T., Sareth, Sina, Larson, Jason, Thomas, Gary
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1750872/
https://ncbi.nlm.nih.gov/pubmed/17179036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606555104
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