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Inhibition of Prohormone Convertases PC1/3 and PC2 by 2,5-Dideoxystreptamine Derivatives

The prohormone convertases PC1/3 and PC2 are eukaryotic serine proteases involved in the proteolytic maturation of peptide hormone precursors and are implicated in a variety of pathological conditions, including obesity, diabetes, and neurodegenerative diseases. In this work, we screened 45 compound...

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Bibliografski detalji
Glavni autori: Vivoli, Mirella, Caulfield, Thomas R., Martínez-Mayorga, Karina, Johnson, Alan T., Jiao, Guan-Sheng, Lindberg, Iris
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286300/
https://ncbi.nlm.nih.gov/pubmed/22169851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.077040
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