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Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release
[Image: see text] Histone deacetylase inhibitors (HDACi) target abnormal epigenetic states associated with a variety of pathologies, including cancer. Here, the development of a prodrug of the canonical broad-spectrum HDACi suberoylanilide hydroxamic acid (SAHA) is described. Although hydroxamic aci...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2015
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4467547/ https://ncbi.nlm.nih.gov/pubmed/25974739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00539 |
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