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The dual mode of action of bistramide A entails severing of filamentous actin and covalent protein modification

This study provides comprehensive characterization of the mode of action of bistramide A and identifies structural requirements of bistramide-based compounds that are responsible for severing actin filaments and inhibiting growth of cancer cells in vitro and in vivo. We rationally designed and assem...

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Detalhes bibliográficos
Main Authors: Rizvi, Syed Alipayam, Courson, David S., Keller, Valerie A., Rock, Ronald S., Kozmin, Sergey A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2393769/
https://ncbi.nlm.nih.gov/pubmed/18334642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710727105
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