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Exploring Hydrogen Peroxide Responsive Thiazolidinone-Based Prodrugs

A novel approach for developing prodrugs based on masked carboxylic acids is described. Rather than using conventional esterase-based activation, thiazolidinone protecting groups have been identified that can reveal carboxylic acid groups upon activation by hydrogen peroxide. This may prove valuable...

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Bibliografiska uppgifter
I publikationen:Chem Commun (Camb)
Huvudupphovsmän: Perez, Christian, Monserrat, Jean-Philippe, Chen, Yao, Cohen, Seth M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659858/
https://ncbi.nlm.nih.gov/pubmed/25811298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc09921d
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