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Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxide
This study details the development of matrix metalloproteinase inhibitor prodrugs (proMMPi) that are activated in the presence of reactive-oxygen species (ROS). Conventional matrix metalloproteinase inhibitors (MMPi) utilize a zinc-binding group (ZBG) that chelates to the catalytic zinc(II) ion of m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3032223/ https://ncbi.nlm.nih.gov/pubmed/21049301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-010-0727-x |
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