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Covalent Modification of Cytochrome C by Reactive Metabolites of Furan

Metabolism of the hepatotoxicant furan leads to protein adduct formation in the target organ. The initial bioactivation step involves cytochrome P450-catalyzed oxidation of furan, generating cis-2-butene-1,4-dial (BDA). BDA reacts with lysine to form pyrrolin-2-one adducts. Metabolic studies indicat...

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書誌詳細
主要な著者: Phillips, Martin B., Sullivan, Mathilde M., Villalta, Peter W., Peterson, Lisa A.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908668/
https://ncbi.nlm.nih.gov/pubmed/24364757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400368r
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