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Covalent Modification of Cytochrome C by Reactive Metabolites of Furan
Metabolism of the hepatotoxicant furan leads to protein adduct formation in the target organ. The initial bioactivation step involves cytochrome P450-catalyzed oxidation of furan, generating cis-2-butene-1,4-dial (BDA). BDA reacts with lysine to form pyrrolin-2-one adducts. Metabolic studies indicat...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3908668/ https://ncbi.nlm.nih.gov/pubmed/24364757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400368r |
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