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Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furan

Furan is a liver toxicant and carcinogen in rodents. Based on these observations and the large potential for human exposure, furan has been classified as a possible human carcinogen. The mechanism of tumor induction by furan is unknown. However, the toxicity requires cytochrome P450 catalyzed oxidat...

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Hlavní autoři: Lu, Ding, Sullivan, Mathilde M., Phillips, Martin B., Peterson, Lisa A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696637/
https://ncbi.nlm.nih.gov/pubmed/19441776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800377v
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