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Identification of a cis-2-butene-1,4-dial-derived glutathione conjugate in the urine of furan-treated rats
The hepatocarcinogen and toxicant, furan, requires metabolic activation to elicit its toxic effects. The available experimental evidence indicate that the overall metabolism of furan is initiated via cytochrome P450 catalyzed oxidation to cis-2-butene-1,4-dial. This α,β-unsaturated dialdehyde reacts...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2006
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532921/ https://ncbi.nlm.nih.gov/pubmed/16978017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx060111x |
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