Molecular Characterization of Inflammatory Myofibroblastic Tumors with Frequent ALK and ROS1 Fusions and Rare Novel RET Gene Rearrangement

Approximately 50% of conventional IMTs harbor ALK gene rearrangement and overexpress ALK. Recently gene fusions involving other kinases have been implicated in the pathogenesis of IMT, including ROS1 and in one patient PDGFRB. However, it remains uncertain if the emerging genotypes correlate with cl...

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Veröffentlicht in:Am J Surg Pathol
Hauptverfasser: Antonescu, Cristina R, Suurmeijer, Albert JH, Zhang, Lei, Sung, Yun-Shao, Jungbluth, Achim A, Travis, William D, Al-Ahmadie, Hikmat, Fletcher, Christopher DM, Alaggio, Rita
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465992/
https://ncbi.nlm.nih.gov/pubmed/25723109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0000000000000404
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