Imidazole C-2 Hydrogen/Deuterium Exchange Reaction at Histidine for Probing Protein Structure and Function with MALDI Mass Spectrometry

We present a mass spectrometric method for analyzing protein structure and function, based on the imidazole C-2 or histidine C(ε(1)) hydrogen/deuterium (H/D) exchange reaction, which is intrinsically second order with respect to the concentrations of the imidazolium cation and OD(−) in D(2)O. The se...

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Vydáno v:Biochemistry
Hlavní autoři: Hayashi, Naoka, Kuyama, Hiroki, Nakajima, Chihiro, Kawahara, Kazuki, Miyagi, Masaru, Nishimura, Osamu, Matsuo, Hisayuki, Nakazawa, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465451/
https://ncbi.nlm.nih.gov/pubmed/24606199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401260f
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