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Conformational Changes in the G Protein-Coupled Receptor Rhodopsin Revealed by Histidine Hydrogen–Deuterium Exchange

G protein-coupled receptors (GPCRs) are activated by ligand binding, allowing extracellular signals to be efficiently transmitted through the membrane to the G protein recognition site, 40 Å away. Utilizing His residues found spaced throughout the GPCR, rhodopsin, we used His hydrogen–deuterium exch...

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Detalhes bibliográficos
Main Authors: Lodowski, David T., Palczewski, Krzysztof, Miyagi, Masaru
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075965/
https://ncbi.nlm.nih.gov/pubmed/20939497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101502v
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